Dietary medium-chain fatty acids reduce hepatic fat accumulation via activation of a CREBH-FGF21 axis

• Main Authors: Ye Cao (Author), Masaya Araki (Author), Yoshimi Nakagawa (Author), Luisa Deisen (Author), Annemarie Lundsgaard (Author), Josephine M. Kanta (Author), Stephanie Holm (Author), Kornelia Johann (Author), Jens Christian Brings Jacobsen (Author), Markus Jähnert (Author), Annette Schürmann (Author), Bente Kiens (Author), Christoffer Clemmensen (Author), Hitoshi Shimano (Author), Andreas M. Fritzen (Author), Maximilian Kleinert (Author)
• Format: Book
• Published: Elsevier, 2024-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Dietary medium-chain fatty acids (MCFAs), characterized by chain lengths of 8-12 carbon atoms, have been proposed to have beneficial effects on glucose and lipid metabolism, yet the underlying mechanisms remain elusive. We hypothesized that MCFA intake benefits metabolic health by inducin...