Manipulation of Cell Physiology Enables Gene Silencing in Well-differentiated Airway Epithelia

• Main Authors: Sateesh Krishnamurthy (Author), Mark A Behlke (Author), Shyam Ramachandran (Author), Aliasger K Salem (Author), Paul B McCray Jr (Author), Beverly L Davidson (Author)
• Format: Book
• Published: Elsevier, 2012-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The application of RNA interference-based gene silencing to the airway surface epithelium holds great promise to manipulate host and pathogen gene expression for therapeutic purposes. However, well-differentiated airway epithelia display significant barriers to double-stranded small-interfering RNA...