GABAergic signaling as therapeutic target for Autism Spectrum Disorders

• Main Authors: Giada eCellot (Author), Enrico eCherubini (Author)
• פורמט: ספר
• יצא לאור: Frontiers Media S.A., 2014-07-01T00:00:00Z.
• נושאים: article
• גישה מקוונת: Connect to this object online.

GABA, the main inhibitory neurotransmitter in the adult brain, early in postnatal life exerts a depolarizing and excitatory action. This depends on accumulation of chloride inside the cell via the cation-chloride importer NKCC1, being the expression of the chloride exporter KCC2 very low at birth. T...