Simvastatin nanoliposome induces myocardial and hepatic toxicities due to its absorption enhancement in mice

• Main Authors: Nuerbiye Tuerdi (Author), Gulinigaer Anwaier (Author), Xing Zhang (Author), Shu Liu (Author), Wanli Shen (Author), Wen Liu (Author), Qiang Shen (Author), Rong Qi (Author)
• Format: Book
• Published: Elsevier, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Nanoliposome is a useful dosage form to increase solubility and absorption of simvastatin (SMV), and consequently improves its therapeutic effects. However, in vivo toxicity of SMV could also be elevated accompanied by the absorption enhancement, which is a decisive factor for the clinical applicati...