The Cyclooctadepsipeptide Anthelmintic Emodepside Differentially Modulates Nematode, Insect and Human Calcium-Activated Potassium (SLO) Channel Alpha Subunits.

• Main Authors: Anna Crisford (Author), Ulrich Ebbinghaus-Kintscher (Author), Eva Schoenhense (Author), Achim Harder (Author), Klaus Raming (Author), Ita O'Kelly (Author), Kelechi Ndukwe (Author), Vincent O'Connor (Author), Robert J Walker (Author), Lindy Holden-Dye (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2015-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The anthelmintic emodepside paralyses adult filarial worms, via a mode of action distinct from previous anthelmintics and has recently garnered interest as a new treatment for onchocerciasis. Whole organism data suggest its anthelmintic action is underpinned by a selective activation of the nematode...