The Cyclooctadepsipeptide Anthelmintic Emodepside Differentially Modulates Nematode, Insect and Human Calcium-Activated Potassium (SLO) Channel Alpha Subunits.

• Hoofdauteurs: Anna Crisford (Auteur), Ulrich Ebbinghaus-Kintscher (Auteur), Eva Schoenhense (Auteur), Achim Harder (Auteur), Klaus Raming (Auteur), Ita O'Kelly (Auteur), Kelechi Ndukwe (Auteur), Vincent O'Connor (Auteur), Robert J Walker (Auteur), Lindy Holden-Dye (Auteur)
• Formaat: Boek
• Gepubliceerd in: Public Library of Science (PLoS), 2015-01-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

The anthelmintic emodepside paralyses adult filarial worms, via a mode of action distinct from previous anthelmintics and has recently garnered interest as a new treatment for onchocerciasis. Whole organism data suggest its anthelmintic action is underpinned by a selective activation of the nematode...