Clozapine Metabolism is Associated With Absolute Neutrophil Count in Individuals With Treatment-Resistant Schizophrenia

• Main Authors: Isabella R. Willcocks (Author), Sophie E. Legge (Author), Mariana Nalmpanti (Author), Lucy Mazzeo (Author), Adrian King (Author), John Jansen (Author), Marinka Helthuis (Author), Michael J. Owen (Author), Michael C. O'Donovan (Author), James T. R. Walters (Author), Antonio F. Pardiñas (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Up to one-third of those with schizophrenia fail to respond to standard antipsychotics and are considered to have treatment-resistant schizophrenia, a condition for which clozapine is the only evidence-based medication. While up to 60% of treated individuals obtain therapeutic benefits from clozapin...