The Class I PI3K inhibitor S14161 induces autophagy in malignant blood cells by modulating the Beclin 1/Vps34 complex

• Main Authors: Siyu Wang (Author), Jie Li (Author), Yanyun Du (Author), Yujia Xu (Author), Yali Wang (Author), Zubin Zhang (Author), Zhuan Xu (Author), Yuanying Zeng (Author), Xinliang Mao (Author), Biyin Cao (Author)
• Format: Book
• Published: Elsevier, 2017-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

S14161 is a pan-Class I PI3K inhibitor that induces blood cancer cell death, but its mechanism is largely unknown. In the present study, we evaluated the role of S14161 in autophagy, an emerging event in cell destination. Multiple myeloma cell lines RPMI-8226, OPM2, KMS11 and leukemia cell line K562...