Synergism Between Interleukin (IL)-17 and Toll-like Receptor 2 and 4 Signals to Induce IL-8 Expression in Cystic Fibrosis Airway Epithelial Cells

• Main Authors: Shota Mizunoe (Author), Tsuyoshi Shuto (Author), Shingo Suzuki (Author), Chizuru Matsumoto (Author), Kenji Watanabe (Author), Keiko Ueno-Shuto (Author), Mary Ann Suico (Author), Kouhei Onuki (Author), Dieter C. Gruenert (Author), Hirofumi Kai (Author)
• Format: Book
• Published: Elsevier, 2012-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cystic fibrosis (CF) is the most common lethal inherited disorder and is caused by mutations in the gene encoding the CF transmembrane regulator (CFTR). The CF lung expresses a profound proinflammatory phenotype that appears to be related to a constitutive hypersecretion of interleukin (IL)-8 from a...