Cholesterol-Containing Nuclease-Resistant siRNA Accumulates in Tumors in a Carrier-free Mode and Silences MDR1 Gene

• Main Authors: Ivan V. Chernikov (Author), Daniil V. Gladkikh (Author), Mariya I. Meschaninova (Author), Alya G. Ven'yaminova (Author), Marina A. Zenkova (Author), Valentin V. Vlassov (Author), Elena L. Chernolovskaya (Author)
• Format: Book
• Published: Elsevier, 2017-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Chemical modifications are an effective way to improve the therapeutic properties of small interfering RNAs (siRNAs), making them more resistant to degradation in serum and ensuring their delivery to target cells and tissues. Here, we studied the carrier-free biodistribution and biological activity...