Cholesterol-Containing Nuclease-Resistant siRNA Accumulates in Tumors in a Carrier-free Mode and Silences MDR1 Gene

Cholesterol-Containing Nuclease-Resistant siRNA Accumulates in Tumors in a Carrier-free Mode and Silences MDR1 Gene

Chemical modifications are an effective way to improve the therapeutic properties of small interfering RNAs (siRNAs), making them more resistant to degradation in serum and ensuring their delivery to target cells and tissues. Here, we studied the carrier-free biodistribution and biological activity...

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Main Authors: Ivan V. Chernikov (Author), Daniil V. Gladkikh (Author), Mariya I. Meschaninova (Author), Alya G. Ven'yaminova (Author), Marina A. Zenkova (Author), Valentin V. Vlassov (Author), Elena L. Chernolovskaya (Author)
Format: Book
Published: Elsevier, 2017-03-01T00:00:00Z.
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3rd Floor Main Library

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