Development of an Alcohol Dilution-Lyophilization Method for the Preparation of mRNA-LNPs with Improved Storage Stability

• Main Authors: Daiki Shirane (Author), Hiroki Tanaka (Author), Yu Sakurai (Author), Sakura Taneichi (Author), Yuta Nakai (Author), Kota Tange (Author), Itsuko Ishii (Author), Hidetaka Akita (Author)
• Format: Book
• Published: MDPI AG, 2023-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The lipid nanoparticle (LNP) is one of the promising nanotechnologies for the delivery of RNA molecules, such as small interfering RNA (siRNA) and messenger RNA (mRNA). A series of LNPs that contain an mRNA encoding the antigen protein of SARS-CoV-2 were already approved as RNA vaccines against this...