Significance of nitric oxide synthases: Lessons from triple nitric oxide synthases null mice

• Main Authors: Masato Tsutsui (Author), Akihide Tanimoto (Author), Masahito Tamura (Author), Hiroshi Mukae (Author), Nobuyuki Yanagihara (Author), Hiroaki Shimokawa (Author), Yutaka Otsuji (Author)
• Format: Book
• Published: Elsevier, 2015-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Nitric oxide (NO) is synthesized by three distinct NO synthases (neuronal, inducible, and endothelial NOSs), all of which are expressed in almost all tissues and organs in humans. The regulatory roles of NOSs in vivo have been investigated in pharmacological studies with non-selective NOS inhibitors...