Synthesis and biological evaluation of pyrrolidine-based T-type calcium channel inhibitors for the treatment of neuropathic pain

• Main Authors: Hak Kyun Yang (Author), Woo Seung Son (Author), Keon Seung Lim (Author), Gun Hee Kim (Author), Eun Jeong Lim (Author), Changdev G. Gadhe (Author), Jae Yeol Lee (Author), Kyu-Sung Jeong (Author), Sang Min Lim (Author), Ae Nim Pae (Author)
• Format: Book
• Published: Taylor & Francis Group, 2018-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The treatment of neuropathic pain is one of the urgent unmet medical needs and T-type calcium channels are promising therapeutic targets for neuropathic pain. Several potent T-type channel inhibitors showed promising in vivo efficacy in neuropathic pain animal models and are being investigated in cl...