Heparanase-2 protein and peptides have a protective effect on experimental glomerulonephritis and diabetic nephropathy

• Main Authors: Baranca Buijsers (Author), Marjolein Garsen (Author), Mark de Graaf (Author), Marinka Bakker-van Bebber (Author), Chunming Guo (Author), Xue Li (Author), Johan van der Vlag (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Introduction: The endothelial glycocalyx degrading enzyme heparanase-1 (HPSE1) is a major contributor to kidney diseases, such as glomerulonephritis and diabetic nephropathy. Therefore, inhibition of HPSE1 could be an interesting therapeutic strategy to treat glomerular diseases. A possible HPSE1 in...