Safety, Pharmacokinetics/Pharmacodynamics, and Absolute Bioavailability of Dexmedetomidine Hydrochloride Nasal Spray in Healthy Subjects: A Randomized, Parallel, Escalating Dose Study

• Үндсэн зохиолчид: Yun Kuang (Зохиогч), Sai-Ying Wang (Зохиогч), Meng-Na Wang (Зохиогч), Guo-Ping Yang (Зохиогч), Can Guo (Зохиогч), Shuang Yang (Зохиогч), Xing-Fei Zhang (Зохиогч), Xiao-Yan Yang (Зохиогч), Qi Pei (Зохиогч), Chan Zou (Зохиогч), Yan-Hong He (Зохиогч), Ying-Yong Zhou (Зохиогч), Kai-Ming Duan (Зохиогч), Jie Huang (Зохиогч)
• Формат: Ном
• Хэвлэсэн: Frontiers Media S.A., 2022-05-01T00:00:00Z.
• Нөхцлүүд: article
• Онлайн хандалт: Connect to this object online.

Background: The present study evaluated the safety, pharmacokinetics/pharmacodynamics (PK/PD), and absolute bioavailability (Fabs) of Dex nasal spray in healthy adult subjects, which serves as a bridge for the subsequent study in children.Methods: Part 1: a double-blind, placebo-controlled, single a...