Safety, Pharmacokinetics/Pharmacodynamics, and Absolute Bioavailability of Dexmedetomidine Hydrochloride Nasal Spray in Healthy Subjects: A Randomized, Parallel, Escalating Dose Study

• Autores principales: Yun Kuang (Autor), Sai-Ying Wang (Autor), Meng-Na Wang (Autor), Guo-Ping Yang (Autor), Can Guo (Autor), Shuang Yang (Autor), Xing-Fei Zhang (Autor), Xiao-Yan Yang (Autor), Qi Pei (Autor), Chan Zou (Autor), Yan-Hong He (Autor), Ying-Yong Zhou (Autor), Kai-Ming Duan (Autor), Jie Huang (Autor)
• Formato: Libro
• Publicado: Frontiers Media S.A., 2022-05-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

Background: The present study evaluated the safety, pharmacokinetics/pharmacodynamics (PK/PD), and absolute bioavailability (Fabs) of Dex nasal spray in healthy adult subjects, which serves as a bridge for the subsequent study in children.Methods: Part 1: a double-blind, placebo-controlled, single a...