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Safety, Pharmacokinetics/Pharmacodynamics, and Absolute Bioavailability of Dexmedetomidine Hydrochloride Nasal Spray in Healthy Subjects: A Randomized, Parallel, Escalating Dose Study

Background: The present study evaluated the safety, pharmacokinetics/pharmacodynamics (PK/PD), and absolute bioavailability (Fabs) of Dex nasal spray in healthy adult subjects, which serves as a bridge for the subsequent study in children.Methods: Part 1: a double-blind, placebo-controlled, single a...

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Main Authors: Yun Kuang (Author), Sai-Ying Wang (Author), Meng-Na Wang (Author), Guo-Ping Yang (Author), Can Guo (Author), Shuang Yang (Author), Xing-Fei Zhang (Author), Xiao-Yan Yang (Author), Qi Pei (Author), Chan Zou (Author), Yan-Hong He (Author), Ying-Yong Zhou (Author), Kai-Ming Duan (Author), Jie Huang (Author)
Format: Book
Published: Frontiers Media S.A., 2022-05-01T00:00:00Z.
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