Toxicity and Dermatokinetic Analysis of Ibrutinib in Human Skin Models

• मुख्य लेखकों: Maria Victória Souto-Silva (लेखक), Elizabete C. I. Bispo (लेखक), Lucas F. F. Albuquerque (लेखक), Stefhani Barcelos (लेखक), Emãnuella M. Garcez (लेखक), Luana S. Quilici (लेखक), Florêncio Figueiredo Cavalcanti Neto (लेखक), Eliza Carla Barroso Duarte (लेखक), Jankerle N. Boeloni (लेखक), Felipe Saldanha-Araujo (लेखक), Guilherme M. Gelfuso (लेखक), Juliana Lott Carvalho (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: MDPI AG, 2024-10-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

<b>Background/Objectives:</b> Ibrutinib (IBR) is a tyrosine kinase inhibitor under investigation in preclinical and clinical settings as an alternative treatment for melanoma. Nevertheless, the limited oral bioavailability of IBR and the need for high doses of the drug to kill melanoma c...