ALOX5 inhibition protects against dopaminergic neurons undergoing ferroptosis

• Main Authors: Kun Li (Author), Meng Wang (Author), Zi-Han Huang (Author), Min Wang (Author), Wan-Yang Sun (Author), Hiroshi Kurihara (Author), Rui-Ting Huang (Author), Rong Wang (Author), Feng Huang (Author), Lei Liang (Author), Yi-Fang Li (Author), Wen-Jun Duan (Author), Rong-Rong He (Author)
• Format: Book
• Published: Elsevier, 2023-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Oxidative disruption of dopaminergic neurons is regarded as a crucial pathogenesis in Parkinson's disease (PD), eventually causing neurodegenerative progression. (-)-Clausenamide (Clau) is an alkaloid isolated from plant Clausena lansium (Lour.), which is well-known as a scavenger of lipid pero...