Vinca herbacea Extract Suppresses NF-kB Signaling and Modulates SIRT1/AMPK/PGC1α Axis to Exert Antidiabetic Effects in Streptozotocin- Induced Diabetic Rats

• Main Authors: Nasim Abedimanesh (Author), Morteza Nouri (Author), Kosar Mohammadnejad (Author), Maedeh Barati (Author), Elham Dabardani (Author), Elahe Kakavand (Author), Mohammad Reza Eskandari (Author), Seyed Hojjat Hosseini (Author), Seyede Momeneh Mohammadi (Author), Iraj Jafari Anarkooli (Author), Maryam Noubarani (Author), Sina Andalib (Author), Alireza Yazdinezhad (Author), Behrooz Motlagh* (Author)
• Format: Book
• Published: Iranian Society of Pharmacognosy, 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background and Objectives: AMPK/SIRT1/PGC1α signaling pathway has an important role in diabetic condition. Some natural products exert anti-diabetic effects by modulating this pathway and also by inhibition of NF-κB. Vinca herbacea has potent antioxidant and anti-inflammatory activities In the prese...