The p110α and p110β Isoforms of Class I Phosphatidylinositol 3-Kinase Are Involved in Toll-Like Receptor 5 Signaling in Epithelial Cells

• Hoofdauteurs: Sabine M. Ivison (Auteur), Mohammed A. S. Khan (Auteur), Nicholas R. Graham (Auteur), Leila A. Shobab (Auteur), Yu Yao (Auteur), Arnawaz Kifayet (Auteur), Laura M. Sly (Auteur), Theodore S. Steiner (Auteur)
• Formaat: Boek
• Gepubliceerd in: Hindawi Limited, 2010-01-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

Background. Bacterial flagellin triggers inflammation in mammalian cells via Toll-like receptor (TLR) 5. Release of the chemokine IL-8 in response to flagellin involves NF-κB, p38 MAP kinase, and phosphatidylinositol 3-kinase (PI3K). However, PI3K has been reported to be either pro- or anti-inflamma...