Novel Carboxylated Chitosan-Based Triptolide Conjugate for the Treatment of Rheumatoid Arthritis

• Main Authors: Lan Zhang (Author), Min Yan (Author), Kun Chen (Author), Qikang Tian (Author), Junying Song (Author), Zijuan Zhang (Author), Zhishen Xie (Author), Yong Yuan (Author), Yaquan Jia (Author), Xin Zhu (Author), Zhenqiang Zhang (Author), Xiangxiang Wu (Author), Huahui Zeng (Author)
• Format: Book
• Published: MDPI AG, 2020-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A new platform for triptolide (TP) delivery was prepared by conjugating TP to a carboxylmethyl chitosan (CMCS). Compared with the natural TP, the TP-conjugate (TP-CMCS) containing TP of ~5 wt% exhibited excellent aqueous solubility (> 5 mg/mL). Results of in vitro experiments showed that TP-CMCS...