Evolution of chemistry and selection technology for DNA-encoded library

• Main Authors: Peixiang Ma (Author), Shuning Zhang (Author), Qianping Huang (Author), Yuang Gu (Author), Zhi Zhou (Author), Wei Hou (Author), Wei Yi (Author), Hongtao Xu (Author)
• Format: Book
• Published: Elsevier, 2024-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

DNA-encoded chemical library (DEL) links the power of amplifiable genetics and the non-self-replicating chemical phenotypes, generating a diverse chemical world. In analogy with the biological world, the DEL world can evolve by using a chemical central dogma, wherein DNA replicates using the PCR rea...