HPMA Copolymer Mebendazole Conjugate Allows Systemic Administration and Possesses Antitumour Activity In Vivo

• Autors principals: Martin Studenovský (Autor), Anna Rumlerová (Autor), Jiřina Kovářová (Autor), Barbora Dvořáková (Autor), Ladislav Sivák (Autor), Libor Kostka (Autor), Daniel Berdár (Autor), Tomáš Etrych (Autor), Marek Kovář (Autor)
• Format: Llibre
• Publicat: MDPI AG, 2022-06-01T00:00:00Z.
• Matèries: article
• Accés en línia: Connect to this object online.

Mebendazole and other benzimidazole antihelmintics, such as albendazole, fenbendazole, or flubendazole, have been shown to possess antitumour activity, primarily due to their microtubule-disrupting activity. However, the extremely poor water-solubility of mebendazole and other benzimidazoles, result...