Motor neurons and glia exhibit specific individualized responses to TDP-43 expression in a Drosophila model of amyotrophic lateral sclerosis

• Main Authors: Patricia S. Estes (Author), Scott G. Daniel (Author), Abigail P. Mccallum (Author), Ashley V. Boehringer (Author), Alona S. Sukhina (Author), Rebecca A. Zwick (Author), Daniela C. Zarnescu (Author)
• Format: Book
• Published: The Company of Biologists, 2013-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

SUMMARY Amyotrophic lateral sclerosis (ALS) is a fatal disease characterized by complex neuronal and glial phenotypes. Recently, RNA-based mechanisms have been linked to ALS via RNA-binding proteins such as TDP-43, which has been studied in vivo using models ranging from yeast to rodents. We have de...