Proniosomal Gel for Topical Delivery of Rutin: Preparation, Physicochemical Characterization and In Vitro Toxicological Profile Using 3D Reconstructed Human Epidermis Tissue and 2D Cells

• Main Authors: Iulia Pinzaru (Author), Alina Tanase (Author), Virgil Enatescu (Author), Dorina Coricovac (Author), Flavia Bociort (Author), Iasmina Marcovici (Author), Claudia Watz (Author), Lavinia Vlaia (Author), Codruta Soica (Author), Cristina Dehelean (Author)
• Format: Book
• Published: MDPI AG, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Rutin (Rut) is a natural flavonol, well-known for its broad-spectrum of therapeutic effects, including antioxidant and antitumoral activities; still, it has a reduced clinical outcome due to its limited solubility in aqueous solutions. To overcome this drawback, this study proposes a novel formulati...