Proniosomal Gel for Topical Delivery of Rutin: Preparation, Physicochemical Characterization and In Vitro Toxicological Profile Using 3D Reconstructed Human Epidermis Tissue and 2D Cells
Rutin (Rut) is a natural flavonol, well-known for its broad-spectrum of therapeutic effects, including antioxidant and antitumoral activities; still, it has a reduced clinical outcome due to its limited solubility in aqueous solutions. To overcome this drawback, this study proposes a novel formulati...
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MDPI AG,
2021-01-01T00:00:00Z.
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| LEADER | 00000 am a22000003u 4500 | ||
|---|---|---|---|
| 001 | doaj_a7908130dc064bd7a1a7ca5c4b6f0724 | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Iulia Pinzaru |e author |
| 700 | 1 | 0 | |a Alina Tanase |e author |
| 700 | 1 | 0 | |a Virgil Enatescu |e author |
| 700 | 1 | 0 | |a Dorina Coricovac |e author |
| 700 | 1 | 0 | |a Flavia Bociort |e author |
| 700 | 1 | 0 | |a Iasmina Marcovici |e author |
| 700 | 1 | 0 | |a Claudia Watz |e author |
| 700 | 1 | 0 | |a Lavinia Vlaia |e author |
| 700 | 1 | 0 | |a Codruta Soica |e author |
| 700 | 1 | 0 | |a Cristina Dehelean |e author |
| 245 | 0 | 0 | |a Proniosomal Gel for Topical Delivery of Rutin: Preparation, Physicochemical Characterization and In Vitro Toxicological Profile Using 3D Reconstructed Human Epidermis Tissue and 2D Cells |
| 260 | |b MDPI AG, |c 2021-01-01T00:00:00Z. | ||
| 500 | |a 10.3390/antiox10010085 | ||
| 500 | |a 2076-3921 | ||
| 520 | |a Rutin (Rut) is a natural flavonol, well-known for its broad-spectrum of therapeutic effects, including antioxidant and antitumoral activities; still, it has a reduced clinical outcome due to its limited solubility in aqueous solutions. To overcome this drawback, this study proposes a novel formulation for rutin as a proniosomal gel for cutaneous applications. The gel was prepared by coacervation phase-separation method and complies with the standard requirements in terms of particle size (140.5 ± 2.56 nm), zeta potential (−27.33 ± 0.09 mV), encapsulation capacity (> 50%), pH (7.002 ± 0.18) and rheological properties. The results showed high biocompatibility of the gel on the 3D reconstructed human epidermis model characterized by increased viability of the cells and a lack of irritant and phototoxic potential. The evaluations on 2D cells confirm the preferential cytotoxic effect of Rut on melanoma cells (IC<sub>50</sub> value = 8.601 µM, nuclear fragmentation) compared to normal keratinocytes. Our data suggest that the proniosomal gel is a promising drug carrier for Rut in the management and prevention of skin disorders. | ||
| 546 | |a EN | ||
| 690 | |a rutin | ||
| 690 | |a antioxidant | ||
| 690 | |a proniosomal gel | ||
| 690 | |a 3D EpiDerm tissues | ||
| 690 | |a melanoma | ||
| 690 | |a keratinocytes | ||
| 690 | |a Therapeutics. Pharmacology | ||
| 690 | |a RM1-950 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Antioxidants, Vol 10, Iss 1, p 85 (2021) | |
| 787 | 0 | |n https://www.mdpi.com/2076-3921/10/1/85 | |
| 787 | 0 | |n https://doaj.org/toc/2076-3921 | |
| 856 | 4 | 1 | |u https://doaj.org/article/a7908130dc064bd7a1a7ca5c4b6f0724 |z Connect to this object online. |