IL-1ra Secreted by ATP-Induced P2Y2 Negatively Regulates MUC5AC Overproduction via PLCβ3 during Airway Inflammation

• Main Authors: Jee-Yeong Jeong (Author), Jiwook Kim (Author), Bokyoum Kim (Author), Joowon Kim (Author), Yusom Shin (Author), Judeok Kim (Author), Siejeong Ryu (Author), Yu-Mi Yang (Author), Kyoung Seob Song (Author)
• Format: Book
• Published: Hindawi Limited, 2016-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Mucus secretion is often uncontrolled in many airway inflammatory diseases of humans. Identifying the regulatory pathway(s) of mucus gene expression, mucus overproduction, and hypersecretion is important to alleviate airway inflammation in these diseases. However, the regulatory signaling pathway co...