Probing Pharmaceutical Strategies to Promote the Skin Delivery of Asiatic Acid from Hydrogels: Enhancement Effects of Organic Amine Counterions, Chemical Enhancers, and Microneedle Pretreatment

• المؤلفون الرئيسيون: Mingming Li (مؤلف), Qiuyue Wang (مؤلف), Naiying Chen (مؤلف), Sicheng Yao (مؤلف), Xinxing Sun (مؤلف), Peng Quan (مؤلف), Yang Chen (مؤلف)
• التنسيق: كتاب
• منشور في: MDPI AG, 2022-11-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

Asiatic acid (AA) is a pentacyclic triterpene isolated from Centella asiatica, holding great promise for treating a variety of skin disorders. However, the dermal application of AA is limited by its poor solubility and permeability. This study aimed to identify a hydrogel formulation for AA and impr...