Design, Synthesis and Biological Evaluation of Biscarbamates as Potential Selective Butyrylcholinesterase Inhibitors for the Treatment of Alzheimer's Disease

• Main Authors: Ana Matošević (Author), Anamarija Knežević (Author), Antonio Zandona (Author), Nikola Maraković (Author), Zrinka Kovarik (Author), Anita Bosak (Author)
• פורמט: ספר
• יצא לאור: MDPI AG, 2022-09-01T00:00:00Z.
• נושאים: article
• גישה מקוונת: Connect to this object online.

As butyrylcholinesterase (BChE) plays a role in the progression of symptoms and pathophysiology of Alzheimer's disease (AD), selective inhibition of BChE over acetylcholinesterase (AChE) can represent a promising pathway in treating AD. The carbamate group was chosen as a pharmacophore because...