Cystathionine γ-lyase inhibits mitochondrial oxidative stress by releasing H2S nearby through the AKT/NRF2 signaling pathway

• Main Authors: Tingting Xiao (Author), Shun Chen (Author), Ge Yan (Author), Junmin Zheng (Author), Qingzhu Qiu (Author), Shujia Lin (Author), Yanfang Zong (Author), Haishuang Chang (Author), Alex Chia Yu Chang (Author), Ying Wu (Author), Cuilan Hou (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cystathionine γ-lyase (CSE) is a major enzyme that produces hydrogen sulfide (H2S). Herein, we report how CSE plays a previously unknown role in regulating the antioxidant effects of the mitochondria in human umbilical vein endothelial cells by releasing H2S nearby under stress conditions. We found...