The prostaglandin E2/EP4 receptor/cyclic AMP/T-type Ca2+ channel pathway mediates neuritogenesis in sensory neuron-like ND7/23 cells

• Main Authors: Kenji Mitani (Author), Fumiko Sekiguchi (Author), Takashi Maeda (Author), Yukari Tanaka (Author), Shigeru Yoshida (Author), Atsufumi Kawabata (Author)
• Format: Book
• Published: Elsevier, 2016-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We investigated mechanisms for the neuritogenesis caused by prostaglandin E2 (PGE2) or intracellular cyclic AMP (cAMP) in sensory neuron-like ND7/23 cells. PGE2 caused neuritogenesis, an effect abolished by an EP4 receptor antagonist or inhibitors of adenylyl cyclase (AC) or protein kinase A (PKA) a...