Survivin inhibition with YM155 ameliorates experimental pulmonary arterial hypertension

• Main Authors: Isabel Blanco (Author), Maribel Marquina (Author), Olga Tura-Ceide (Author), Elisabet Ferrer (Author), Ana M. Ramírez (Author), Manuel Lopez-Meseguer (Author), Maria Callejo (Author), Francisco Perez-Vizcaino (Author), Victor Ivo Peinado (Author), Joan Albert Barberà (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Imbalance between cell proliferation and apoptosis underlies the development of pulmonary arterial hypertension (PAH). Current vasodilator treatment of PAH does not target the uncontrolled proliferative process in pulmonary arteries. Proteins involved in the apoptosis pathway may play a...