Modifications of the Method for Calculating Absolute Drug Bioavailability

• Main Authors: Wei Jiang (Author), Juan-juan Yang (Author), Lei Cao (Author), Xue Xiao (Author), Xiao-lian Shi (Author), Yong-xiao Cao (Author)
• Format: Book
• Published: Frontiers Media S.A., 2016-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Purpose: Absolute bioavailability (F) is calculated as the ratio of the area under the plasma drug concentration-time curve (AUC) between extravascular administration and intravenous injection. However, as distribution of a drug after intravenous administration does not reach an equilibrium in the b...