Efficacy and safety of re-treatment with the same artemisinin-based combination treatment (ACT) compared with an alternative ACT and quinine plus clindamycin after failure of first-line recommended ACT (QUINACT): a bicentre, open-label, phase 3, randomised controlled trial

• Main Authors: Hypolite Muhindo Mavoko, DrPhD (Author), Carolyn Nabasumba, MD (Author), Raquel Inocêncio da Luz, PhD (Author), Halidou Tinto, PhD (Author), Umberto D'Alessandro, ProfPhD (Author), Andrew Kambugu, MD (Author), Vito Baraka, MSc (Author), Anna Rosanas-Urgell, PhD (Author), Pascal Lutumba, ProfPhD (Author), Jean-Pierre Van geertruyden, PhD (Author)
• Format: Book
• Published: Elsevier, 2017-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Summary: Background: Quinine or alternative artemisinin-based combination treatment (ACT) is the recommended rescue treatment for uncomplicated malaria. However, patients are often re-treated with the same ACT though it is unclear whether this is the most suitable approach. We assessed the efficacy...