The selective orexin receptor 1 antagonist ACT-335827 in a rat model of diet-induced obesity associated with metabolic syndrome

• Main Authors: Michel Alexander Steiner (Author), Carla eSciarretta (Author), Anne ePasquali (Author), Francois eJenck (Author)
• Format: Book
• Published: Frontiers Media S.A., 2013-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The orexin system regulates feeding, nutrient metabolism and energy homeostasis. Acute pharmacological blockade of orexin receptor 1 (OXR-1) in rodents induces satiety and reduces normal and palatable food intake. Genetic OXR-1 deletion in mice improves hyperglycemia under high-fat (HF) diet conditi...