Glucagon receptor antagonism impairs and glucagon receptor agonism enhances triglycerides metabolism in mice

• Main Authors: Katrine D. Galsgaard (Author), Emilie Elmelund (Author), Christian D. Johansen (Author), Anna B. Bomholt (Author), Hüsün S. Kizilkaya (Author), Frederik Ceutz (Author), Jenna E. Hunt (Author), Hannelouise Kissow (Author), Marie Winther-Sørensen (Author), Charlotte M. Sørensen (Author), Thomas Kruse (Author), Jesper F. Lau (Author), Mette M. Rosenkilde (Author), Cathrine Ørskov (Author), Christina Christoffersen (Author), Jens J. Holst (Author), Nicolai J. Wewer Albrechtsen (Author)
• Format: Book
• Published: Elsevier, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Treatment with glucagon receptor antagonists (GRAs) reduces blood glucose but causes dyslipidemia and accumulation of fat in the liver. We investigated the acute and chronic effects of glucagon on lipid metabolism in mice. Methods: Chronic effects of glucagon receptor signaling on lipid m...