A comprehensive assessment of the SOD1G93A low-copy transgenic mouse, which models human amyotrophic lateral sclerosis

• Main Authors: Abraham Acevedo-Arozena (Author), Bernadett Kalmar (Author), Shafa Essa (Author), Thomas Ricketts (Author), Peter Joyce (Author), Rosie Kent (Author), Claire Rowe (Author), Andy Parker (Author), Anna Gray (Author), Majid Hafezparast (Author), Julian R. Thorpe (Author), Linda Greensmith (Author), Elizabeth M. C. Fisher (Author)
• Format: Book
• Published: The Company of Biologists, 2011-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

SUMMARY Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder that results in the death of motor neurons in the brain and spinal cord. The disorder generally strikes in mid-life, relentlessly leading to paralysis and death, typically 3-5 years after diagnosis. No effective...