MicroRNA-20b Promotes Cardiac Hypertrophy by the Inhibition of Mitofusin 2-Mediated Inter-organelle Ca2+ Cross-Talk

• Main Authors: Yue Qiu (Author), Rongchao Cheng (Author), Chaoqi Liang (Author), Yuan Yao (Author), Wenhao Zhang (Author), Jie Zhang (Author), Mingyu Zhang (Author), Baiyan Li (Author), Chaoqian Xu (Author), Rong Zhang (Author)
• Format: Book
• Published: Elsevier, 2020-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

MicroRNA (miRNA) and mitofusin-2 (Mfn2) are important in the development of cardiac hypertrophy, but the target relationship and mechanism associated with Ca2+ handling between SR and mitochondria under hypertrophic condition is not established. Mfn2 expression, Mfn2-mediated interorganelle Ca2+ cro...