The Beneficial Effect of Lomitapide on the Cardiovascular System in LDLr^−/− Mice with Obesity

• Główni autorzy: Undral Munkhsaikhan (Autor), Young In Kwon (Autor), Amal M. Sahyoun (Autor), María Galán (Autor), Alexis A. Gonzalez (Autor), Karima Ait-Aissa (Autor), Ammaar H. Abidi (Autor), Adam Kassan (Autor), Modar Kassan (Autor)
• Format: Książka
• Wydane: MDPI AG, 2023-06-01T00:00:00Z.
• Hasła przedmiotowe: article
• Dostęp online: Connect to this object online.

Objectives: Homozygous familial hypercholesteremia (HoFH) is a rare, life-threatening metabolic disease, mainly caused by a mutation in the LDL receptor. If untreated, HoFH causes premature death from acute coronary syndrome. Lomitapide is approved by the FDA as a therapy to lower lipid levels in ad...