The Beneficial Effect of Lomitapide on the Cardiovascular System in LDLr^−/− Mice with Obesity

• Main Authors: Undral Munkhsaikhan (Author), Young In Kwon (Author), Amal M. Sahyoun (Author), María Galán (Author), Alexis A. Gonzalez (Author), Karima Ait-Aissa (Author), Ammaar H. Abidi (Author), Adam Kassan (Author), Modar Kassan (Author)
• Format: Book
• Published: MDPI AG, 2023-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objectives: Homozygous familial hypercholesteremia (HoFH) is a rare, life-threatening metabolic disease, mainly caused by a mutation in the LDL receptor. If untreated, HoFH causes premature death from acute coronary syndrome. Lomitapide is approved by the FDA as a therapy to lower lipid levels in ad...