Absolute oral bioavailability of milvexian spray‐dried dispersion formulation under fasted and fed conditions in healthy adult participants: An intravenous microtracer approach

• Main Authors: Praneeth Jarugula (Author), Sharif Soleman (Author), Hyunmoon Back (Author), Lisa J. Christopher (Author), Dara Hawthorne (Author), Ronald Aronson (Author), Anh Bui (Author), Angela Mirzac (Author), Antoinette Ajavon‐Hartmann (Author), Vidya Perera (Author), Bindu Murthy (Author), Samira Merali (Author)
• Format: Book
• Published: Wiley, 2024-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Milvexian is an oral, small‐molecule factor XIa inhibitor being developed to prevent thromboembolic events. This study assessed the absolute bioavailability (F) of milvexian following single doses of milvexian spray‐dried dispersion (SDD) formulation under fed and fasted conditions, and mil...