Clinically relevant enantiomer specific R‐ and S‐praziquantel pharmacokinetic drug‐drug interactions with efavirenz and ritonavir

• Main Authors: Chenai Sheilla Mutiti (Author), Nyasha Nicole Kapungu (Author), Comfort Ropafadzo Kanji (Author), Nadina Stadler (Author), Julia Stingl (Author), Charles Nhachi (Author), James Hakim (Author), Collen Masimirembwa (Author), Roslyn Stella Thelingwani (Author)
• Format: Book
• Published: Wiley, 2021-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract We conducted a clinical study to determine the effect of efavirenz and ritonavir on the pharmacokinetics of R‐ and S‐PZQ in healthy male participants. This was toward evaluating the risk of drug‐drug interactions, which may occur after PZQ administration to HIV patients on efavirenz or rito...