Evaluation of the Potency of Anti-HIV and Anti-HCV Drugs to Inhibit P-Glycoprotein Mediated Efflux of Digoxin in Caco-2 Cell Line and Human Precision-Cut Intestinal Slices

• Главные авторы: Martin Huličiak (Автор), Ivan Vokřál (Автор), Ondřej Holas (Автор), Ondřej Martinec (Автор), František Štaud (Автор), Lukáš Červený (Автор)
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• Опубликовано: MDPI AG, 2022-02-01T00:00:00Z.
• Предметы: article
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The inhibition of P-glycoprotein (ABCB1) could lead to increased drug plasma concentrations and hence increase drug toxicity. The evaluation of a drug's ability to inhibit ABCB1 is complicated by the presence of several transport-competent sites within the ABCB1 binding pocket, making it diffic...