STA-9090 in combination with a statin exerts enhanced protective effects in rats fed a high-fat diet and exposed to diethylnitrosamine and thioacetamide

• Main Authors: Amir Mohamed Abdelhamid (Author), Sameh Saber (Author), Rabab S. Hamad (Author), Mustafa Ahmed Abdel-Reheim (Author), Abousree T. Ellethy (Author), Maha M. Amer (Author), Mohamed R. Abdel-Hamed (Author), Enas A. Mohamed (Author), Syed Suhail Ahmed (Author), Hossam A. Elsisi (Author), Mostafa M. Khodeir (Author), Abdullah S. Alkhamiss (Author), AlSalloom A. A. (Author), Mawahib Ahmed Elawad Abu Elgasim (Author), Zainab H. Almansour (Author), Basem H. Elesawy (Author), Elsayed A. Elmorsy (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

IntroductionLiver fibrosis is a significant global health burden that lacks effective therapies. It can progress to cirrhosis and hepatocellular carcinoma (HCC). Aberrant hedgehog pathway activation is a key driver of fibrogenesis and cancer, making hedgehog inhibitors potential antifibrotic and ant...