Novel [(N-alkyl-3-indolylmethylene)hydrazono]oxindoles arrest cell cycle and induce cell apoptosis by inhibiting CDK2 and Bcl-2: synthesis, biological evaluation and in silico studies

• Main Authors: Tarfah Al-Warhi (Author), Mahmoud F. Abo-Ashour (Author), Hadia Almahli (Author), Ohoud J. Alotaibi (Author), Mohammad M. Al-Sanea (Author), Ghada H. Al-Ansary (Author), Hanaa Y. Ahmed (Author), Mahmoud M. Elaasser (Author), Wagdy M. Eldehna (Author), Hatem A. Abdel-Aziz (Author)
• Format: Book
• Published: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

As a continuation for our previous work, a novel set of N-alkylindole-isatin conjugates (7, 8a-c, 9 and 10a-e) is here designed and synthesised with the prime aim to develop more efficient isatin-based antitumor candidates. Utilising the SAR outputs from the previous study, our design here is based...