Novel [(N-alkyl-3-indolylmethylene)hydrazono]oxindoles arrest cell cycle and induce cell apoptosis by inhibiting CDK2 and Bcl-2: synthesis, biological evaluation and in silico studies

As a continuation for our previous work, a novel set of N-alkylindole-isatin conjugates (7, 8a-c, 9 and 10a-e) is here designed and synthesised with the prime aim to develop more efficient isatin-based antitumor candidates. Utilising the SAR outputs from the previous study, our design here is based...

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Principais autores: Tarfah Al-Warhi (Autor), Mahmoud F. Abo-Ashour (Autor), Hadia Almahli (Autor), Ohoud J. Alotaibi (Autor), Mohammad M. Al-Sanea (Autor), Ghada H. Al-Ansary (Autor), Hanaa Y. Ahmed (Autor), Mahmoud M. Elaasser (Autor), Wagdy M. Eldehna (Autor), Hatem A. Abdel-Aziz (Autor)
Formato: Livro
Publicado em: Taylor & Francis Group, 2020-01-01T00:00:00Z.
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3rd Floor Main Library

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