Allosterism vs. Orthosterism: Recent Findings and Future Perspectives on A2B AR Physio-Pathological Implications

• Main Authors: Elisabetta Barresi (Author), Claudia Martini (Author), Federico Da Settimo (Author), Giovanni Greco (Author), Sabrina Taliani (Author), Chiara Giacomelli (Author), Maria Letizia Trincavelli (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The development of GPCR (G-coupled protein receptor) allosteric modulators has attracted increasing interest in the last decades. The use of allosteric modulators in therapy offers several advantages with respect to orthosteric ones, as they can fine-tune the tissue responses to the endogenous agoni...