Refining the structure−activity relationships of 2-phenylcyclopropane carboxylic acids as inhibitors of O-acetylserine sulfhydrylase isoforms

• Main Authors: Joana Magalhães (Author), Nina Franko (Author), Giannamaria Annunziato (Author), Marco Pieroni (Author), Roberto Benoni (Author), Anna Nikitjuka (Author), Andrea Mozzarelli (Author), Stefano Bettati (Author), Anna Karawajczyk (Author), Aigars Jirgensons (Author), Barbara Campanini (Author), Gabriele Costantino (Author)
• Format: Book
• Published: Taylor & Francis Group, 2019-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The lack of efficacy of current antibacterials to treat multidrug resistant bacteria poses a life-threatening alarm. In order to develop enhancers of the antibacterial activity, we carried out a medicinal chemistry campaign aiming to develop inhibitors of enzymes that synthesise cysteine and belong...