Trans-heterozygosity for mutations enhances the risk of recurrent/chronic pancreatitis in patients with Cystic Fibrosis

• Main Authors: Valentina Maria Sofia (Author), Cecilia Surace (Author), Vito Terlizzi (Author), Letizia Da Sacco (Author), Federico Alghisi (Author), Antonella Angiolillo (Author), Cesare Braggion (Author), Natalia Cirilli (Author), Carla Colombo (Author), Antonella Di Lullo (Author), Rita Padoan (Author), Serena Quattrucci (Author), Valeria Raia (Author), Giuseppe Tuccio (Author), Federica Zarrilli (Author), Anna Cristina Tomaiuolo (Author), Antonio Novelli (Author), Vincenzina Lucidi (Author), Marco Lucarelli (Author), Giuseppe Castaldo (Author), Adriano Angioni (Author)
• Format: Book
• Published: BMC, 2018-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Recurrent (RP) and chronic pancreatitis (CP) may complicate Cystic Fibrosis (CF). It is still unknown if mutations in genes involved in the intrapancreatic activation of trypsin (IPAT) or in the pancreatic secretion pathway (PSP) may enhance the risk for RP/CP in patients with CF...