Characterization of the high-affinity anti-CTLA-4 monoclonal antibody JS007 for immune checkpoint therapy of cancer

• Main Authors: Jiawei Guan (Author), Hongchuan Liu (Author), Yan Chai (Author), Jie Yu (Author), Jian Yao (Author), Jing Wang (Author), Zhiwei Pan (Author), Jing Zhang (Author), Yuehua Zhou (Author), Hui Liu (Author), Sheng Yao (Author), Jianxun Qi (Author), Hui Feng (Author), George F. Gao (Author), Qihui Wang (Author), Yi Shi (Author), Shuguang Tan (Author)
• Format: Book
• Published: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

ABSTRACTCytotoxic T lymphocyte-associated antigen 4 (CTLA-4) is a critical inhibitory checkpoint molecule, and monoclonal antibodies (mAbs) targeting CTLA-4 that restore anti-tumor T cell immunity have achieved clinical success. Here, we report a humanized IgG1 mAb, namely JS007, with high binding a...