Formulation and Efficacy of Catalase-Loaded Nanoparticles for the Treatment of Neonatal Hypoxic-Ischemic Encephalopathy

• Main Authors: Andrea Joseph (Author), Chris W. Nyambura (Author), Danielle Bondurant (Author), Kylie Corry (Author), Denise Beebout (Author), Thomas R. Wood (Author), Jim Pfaendtner (Author), Elizabeth Nance (Author)
• Format: Book
• Published: MDPI AG, 2021-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Neonatal hypoxic-ischemic encephalopathy is the leading cause of permanent brain injury in term newborns and currently has no cure. Catalase, an antioxidant enzyme, is a promising therapeutic due to its ability to scavenge toxic reactive oxygen species and improve tissue oxygen status. However, upon...