Design of semisynthetic derivatives of the Amaryllidaceae alkaloid ambelline and exploration of their in vitro cytotoxic activities

• Główni autorzy: Aneta Ritomská (Autor), Darja Koutova (Autor), Jana Křoustková (Autor), Karel Královec (Autor), Darina Muthná (Autor), Jiří Kuneš (Autor), Lucie Nováková (Autor), Radim Havelek (Autor), Lucie Cahlíková (Autor)
• Format: Książka
• Wydane: Elsevier, 2023-08-01T00:00:00Z.
• Hasła przedmiotowe: article
• Dostęp online: Connect to this object online.

Ambelline, an alkaloid from the Amaryllidaceae family with a crinane-type skeleton, has not yet demonstrated any outstanding biological activity. However, its analogues prepared by derivatization of the C-11 hydroxyl group show different interesting effects. Continuing our earlier work, twelve novel...