Design of semisynthetic derivatives of the Amaryllidaceae alkaloid ambelline and exploration of their in vitro cytotoxic activities

• Main Authors: Aneta Ritomská (Author), Darja Koutova (Author), Jana Křoustková (Author), Karel Královec (Author), Darina Muthná (Author), Jiří Kuneš (Author), Lucie Nováková (Author), Radim Havelek (Author), Lucie Cahlíková (Author)
• Format: Book
• Published: Elsevier, 2023-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Ambelline, an alkaloid from the Amaryllidaceae family with a crinane-type skeleton, has not yet demonstrated any outstanding biological activity. However, its analogues prepared by derivatization of the C-11 hydroxyl group show different interesting effects. Continuing our earlier work, twelve novel...