Early ascorbic acid administration prevents vascular endothelial cell damage in septic mice

• Main Authors: Yutaro Madokoro (Author), Chinatsu Kamikokuryo (Author), Shuhei Niiyama (Author), Takashi Ito (Author), Satoshi Hara (Author), Hiroshi Ichinose (Author), Yasuyuki Kakihana (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Oxidation of BH4, a cofactor of nitric oxide synthase (NOS), produces reactive oxygen species (ROS) through uncoupling of NOS and affects vascular endothelial dysfunction. Ascorbic acid (AsA) inhibits the oxidation of BH4 and reduces ROS. However, the kinetic changes of BH4 in sepsis and its effect...